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The top 12 most amazing Israeli medical advances

Israel is a powerhouse in medical innovation. We give you a dozen standouts from a field with many exciting, game-changing candidates.
By Abigail Klein Leichman
Israeli ingenuity is responsible for some of the world’s most amazing medical advances.

Whether they’re futuristic, such as Given Imaging’s PillCam capsule endoscopy or Itamar Medical’s fingertip monitors for sleep disorders and cardiac issues — or cleverly simple, such as First Care Products’ Emergency Bandage – blue-and-white inventions are changing the face of healthcare in hospitals, doctors’ offices, homes and even battlefields worldwide.

“It’s almost a cliché to say Israel is an excellent place for medical innovation,” says Eran Perry, managing director at Israel Health Care Ventures (IHCV), one of the largest venture capital funds in the country.

“But if you look at [global] statistics, it’s evident — from total expenditure on civilian R&D, where we are ranked first; to human infrastructure and entrepreneurship, where we rank in the top five. You can see the results in patents. We are first in the world for medical device patents per capita, and second in Europe for bio-pharma.”

About 1,000 Israeli companies are in healthcare or life-science products, including 700 in medical devices. Approximately half are already generating revenue.

“There has been an ecosystem created for life sciences, so these 1,000 companies don’t exist in a vacuum but in an environment where they have access to everything they need — engineering, labs, regulatory consultants, manufacturing consultants,” Perry tells ISRAEL21c. “Many young companies can be a one-man show until they get to the clinical trial stage, relying on this excellent ecosystem around them. You can see Israeli companies reaching the same stage as American ones with a fraction of the capital investment.”

IHCV reviews 200 to 300 new opportunities per year. Perry estimates that 60 to 70 Israeli healthcare companies are founded annually. Proceeds from mergers and acquisitions involving Israeli healthcare companies totalled around $1 billion in the past year.

That’s why ISRAEL21c had a hard time narrowing the field to this top 12 list of the most significant recent Israeli contributions to the medical field.

We have chosen products already on, or very near, the market. If you’ve got other companies you think also deserve a mention please don’t hesitate to add them to the comments section below.

And watch for a future top 10 list of the most exciting Israeli medical-device and pharmaceutical developments just around the corner.

And now … ISRAEL21c’s top 12 Israeli medical innovations, in alphabetical order.

1. ApiFix system to correct severe curvature of the spine (scoliosis) minimizes risks, scar size, complications, recovery time and cost. The miniature ratchet mechanism has successfully been implanted in 15 patients so far. Limited sales of the product have begun while clinical trials are in the last stages.

2. Argo Medical Technologies’ Rewalk robotic exoskeleton from was featured on the hit TV show “Glee” and enabled paraplegic runners in London and Tel Aviv to complete marathons. The ReWalk Rehabilitation model currently is used by patients in rehab centers from New York to Dusseldorf. ReWalk Personal, for everyday home use, is available throughout Europe and awaiting FDA clearance in the United States.

3. Gamida Cell is developing stem-cell therapy products to treat blood cancers, solid tumors, non-malignant blood diseases such as sickle-cell anemia, autoimmune diseases and genetic metabolic diseases. On Sept. 9, the first patient was successfully transplanted at Duke University Medical Center (North Carolina) in the second Phase I/II study of NiCord, Gamida’s experimental treatment for blood cancers.

4. GI View Aer-O-Scope disposable colorectal cancer screening device, now in US trials, will make lifesaving colonoscopy screenings cheaper, safer and more accessible worldwide. The self-navigating, flexible Aer-O-Scope removes the risk of perforating the colon, provides superior imaging and can be used by a trained nurse or technician so a gastroenterologist does not have to be present.

5. IceCure Medical’s IceSense3
has been used by US doctors since 2011 to remove benign breast lumps in a 10-minute ultrasound-guided procedure that penetrates the tumor and engulfs it with ice. The system is being clinically tested over the next few years against small malignant breast tumors as well. The procedure is done in a doctor’s office, clinic or breast center, and the patient can get up and leave afterward with no recovery period or post-care.

6. InSightec’s ExAblate OR uses MRI-guided focused ultrasound to destroy tumors and uterine fibroid cysts without surgery. The company has begun a Phase III trial of its next product, ExAblate Neuro, to cure essential tremor — a common movement disorder – using the same non-invasive technology to significantly lower risk of infection, hemorrhage and brain damage.


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