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Here’s how a five-day diet that mimics fasting may ‘reboot’ the body and reduce cancer risk

Scientists say they have developed a safe way to fast and lose weight using a five-day diet. Here’s a breakdown of the “Fasting Mimicking Diet.” (Jhaan Elker/The Washington Post)

Fasting has long been acclaimed as an effective way to lose weight, improve the immune system and boost brain function. But doctors have been loathe to recommend it because of the dangers associated with such extreme dieting.

Now scientists say they’ve developed a five-day, once-a-month diet that mimics fasting — and is safe.

In the study, which was published in the journal Cell Metabolism and funded by the National Institute on Aging, participants who intermittently fasted for three months had reduced risk factors for an amazing range of issues: aging, cancer, diabetes, cardiovascular disease. While the number of study participants was small — only 19 who tried the diet — the results are so promising that the University of Southern California researcher who helped develop the regimen is already talking about trying to get approval from the Food and Drug Administration so that it can be recommended for patients.

Co-author Valter D. Longo, who studies longevity, described the idea behind fasting as a way to “reboot” a person’s body by clearing out damaged cells and regenerating new ones.

“It’s about reprogramming the body so it enters a slower aging mode, but also rejuvenating it…,” he said. “It’s not a typical diet because it isn’t something you need to stay on.”

The diet described in the study — which the researchers dubbed the “Fasting Mimicking Diet” — isn’t quite as extreme as actual fasting. It works like this:

For 25 days out of the month dieters can eat as they normally would — the good, bad and in-between. Then for day one of the diet, they would eat 1,090 calories: 10 percent protein, 56 percent fat and 34 percent carbohydrates. For days two through five, 725 calories: 9 percent protein, 44 percent fat, 47 percent carbohydrates.

In the study, participants consumed a lot of vegetable soup, kale crackers and chamomile tea. The calories consumed are 54 to 34 of what a typical person might eat in a day.

The participants in the study did this for three cycles or three months before the researchers measured them and found decreased risk factors and biomarkers for disease with no major adverse side effects.


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