‘Potentially Revolutionary’ Leukemia Treatment Based on Israeli Research Revealed
JNS.org – A cancer study showing results hailed this week as potentially revolutionary for the treatment for leukemia is based on research undertaken by Weizmann Institute Prof. Zelig Eshhar.
An article in the journalScience Translational Medicine outlines how researchers from the University of Pennsylvania’s Abramson Cancer Center and the Perelman School of Medicine found that 27 out of 29 advanced leukemia patients either went into remission, or saw their illness go away completely after their T-cells were modified genetically, a success rate of nearly 94 percent. In the study carried out at the Fred Hutchinson Cancer Research Center in Seattle, Wa. the cells were equipped with synthetic molecules the were able to destroy the tumor cells, particularly in cases of acute lymphoblastic leukemia (ALL).
These results are not surprising for Prof. Eshhar, who pioneered the idea with a 1989 study published in the Proceedings of the National Academy of Sciences, in which he replaced the T cell’s natural receptor with one of his choice, showing that T-cells can be engineered to attach to any entity. Eshhar won the Jewish state’s prestigious Israel Prize for his research in 2015.
“I’m not surprised to hear about the results,” he said, the Times of Israel reported. “In our lab, we cured many rats and mice of cancer. I have been saying for years
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